Genotyping using target-specific microarrays can be more efficient and cost-effective than full genome sequencing for determining differences in the genetic makeup of pathogens. A few examples of our custom target microarrays for genotyping applications include:
InDevR is developing a new, multiplexed influenza diagnostic, FluChip-8G, with the goal of bringing a high information content influenza diagnostic closer to patients. Multiplexed analysis of viral genes genes within a 4 hour assay will provide a remarkable level of genotyping detail in a straight-forward, cost effective format. Based on a limited pre-clinical assessment, the assay accurately identifies virus type and subtype, including B lineage (Yamagata or Victoria), and anti-viral susceptibility.
View FluChip related publications here.
Shiga toxin-producing Escherichia coli:
Testing for shiga toxin-producing E. coli was performed using the ampliPHOX® Colorimetric Detection Technology.
“O-antigen and virulence profiling of Shiga toxin-producing Escherichia coli by a rapid and cost–effective DNA microarray colorimetric method”, Frontiers in Cellular and Infection Microbiology by Quiñones B, et al (2012)
Our webinar from May 1, 2013, with Beatriz Quiñones presenting on “Rapid & Cost-Effective Genotyping of Shiga Toxigenic Escherichia coli (STEC) with Low-Density Microarrays” can be viewed here.
Crimean-Congo Hemorrhagic Fever Virus (CCHFV):
Researchers at USAMRIID have utilized target-specific microarrays and InDevR’s ampliPHOX colorimetric detection technology for detection and differentiation of CCHFV. View their most recent poster from the ASM Biodefense Conference (2014) here.